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2008/2009 U.S. MSPPSA report on Protein Expression and Purification

380 pages, 250 graphs and tables

Published: February 29, 2008

Price: $4795

 

Comprehensive Analysis of the N. American Protein Expression & Purification Market

A thorough investigation into this exciting growth business, this new market research report places the current North American protein expression kit market at over $200 million, doubling since our last report was published in 2003. Of the 135,000 life science researchers working in North America, 49,890 are currently using protein expression and associated purification techniques. The new 380 page MSPPSA Report is based upon more than 400 end-user interviews conducted during December 2007. The extensive database itemizes approximately $14 million spent by respondents themselves on these products. This rich dataset enables a detailed examination of this market and its important segments.

 

The report contains individual sections for the five most common cell systems - mammalian, insect, yeast, prokaryotic, and cell-free or in-vitro expression systems. As the following graph shows, usage is spread over five different expression systems, with prokaryotic still the most widespread although mammalian now accounts for the largest dollar share of the market.

 

 

We are also seeing growing interest in cell-free expression systems, amongst both end-users and our clients and we have added many more questions and technical detail to this burgeoning area.

 

We have also expanded coverage in this report to include the associated area of purification of expressed proteins. Researchers' purification budgets in this market sector are even larger than those for protein expression. The following graph shows the distribution of annual purification budgets by type of organization.

 

 

Respondents could provide data for their individual usage, or for the usage of their entire laboratory. In the following table, you can see the summary of the annual dollar spend by the 406 respondents completing this portion of the survey, providing budgets for a total of 1,337 researchers and normalized to a 'per researcher' basis.

 

Annual Dollar Spend per Researcher for Associated Purification Products, by Product Category

Cell

System

# Respondents

# Researchers

Range

Total Spend

Mean

Median

Columns

357

1,192

$2-$105,000

$3,403,953

$2,856

$537

Instrumentation

245

858

$5-$50,000

$2,009,506

$2,342

$400

Lysis system

295

970

$4-$50,000

$832,987

$859

$250

Total

406

1,337

 

$6,246,446

 

 

 

The budget information provided by respondents includes all major suppliers they use, enabling us to calculate shares of mentions as well as dollar market shares for each segment of the protein expression as well as the associated protein purification market. In the graph below, we see the current dollar market share for the most widely used system, prokaryotic protein expression:

 

 

In this traditional segment, Invitrogen is the market leader, but this supplier's share varies dramatically across expression systems, dominating in some, and being a minor player in others. Where this company is strongest and weakest? Can you successfully compete not knowing these shares in each segment you operate in?

 

Speaking of competition, we asked respondents to rank the importance of ten factors in selecting a supplier for protein expression and purification products. We then asked respondents to identify the supplier they were familiar with and then to select the supplier they felt ranked best for the five factors most important to them as individuals. We gathered reams of data concerning all leading suppliers, ranked by respondents in areas of particular importance to them. This approach yields far more meaningful data than a shotgun approach asking respondents to rank numerous suppliers and areas, many of which they are unfamiliar with, or feel are unimportant.

 

Top Three Factors in Selecting Protein Expression or Purification System Supplier

Factor

Mean

Median

Mode

Reliable performance

1.7

1

1

Consistent quality

1.8

1

1

Ease of use

2.3

2

1

 

In the following graph, we see how suppliers are ranked for one of these ten factors, the number of literature references. Once again, we see that Invitrogen dominates this ranking - but how important are literature references to bioresearchers. This is not one of the top three factors, as shown in the prior table. Do you know how important this factor is to customers?

 

 

The report includes sections covering extensive technical aspects of protein expression. For example, in the following table, we see the yield typically obtained with various cell systems used in protein expression. One reason for the continued wide usage of prokaryotic cell systems is clear - its relatively high yield.

 

Yield of Expressed Proteins (in Milligrams), by Cell System

System

# Rows

Minimum

Maximum

Mean

Median

Mode

Prokaryotic

269

0.005

2,000

53.0

5.00

1

Mammalian

162

0.0005

1,000

34.4

1.00

1

Insect

62

0.001

100

8.8

1.75

1

Yeast

50

0.001

5,000

145.0

5.75

1

Cell-free

49

0.00001

500

16.5

1.00

1

Plant

11

0.05

1,000

113.4

1.00

1

Other

3

1.0

50

23.7

-

-

Total

606

0.00001

5,000

49.1

3.5

1

 

An additional section is devoted to studying the technical applications for these expression products. Topics covered include the types of protein expressed, the purification methods utilized and purification yield obtained, the number of constructs expressed monthly, and the use of automated purification systems. Also investigated were the requirements for type of activity and post-translational modifications, finishing with an open-ended probe regarding downstream applications. The broad cross-section of researchers yields hundreds of particularly valuable, detailed, and specific comments.

 

As useful as closed-ended questions are, we prefer using open-ended questions to probe for additional information. The open-ended probe shown at the bottom of the screen shot below is one such example. From this, we collected over 440 comments from respondents filled with valuable reasons for selecting the cell systems used for expression.

 

 

Reading these comments is equivalent to spending weeks of time in the field with end-users and provides essential insight for suppliers. Additional open-ended questions in the survey probed reasons for respondents' technical choices in designing their expression experiments as well as probes of desired improvements in both expression systems and purification of expressed proteins.

 

An entire section of the report is dedicated to future purchase plans and we use this data to project future growth rates and lines of products forecast to grow least and most rapidly. Over-confident suppliers will ignore these statistics at their own peril, while market-savvy suppliers will use this data to increase their market share and avoid market dead zones.

 

These are a few of the conclusions of a new 380-page study, part of PhorTech's MSPPSA series. This series has been developed over the past 14 years to systematically measure market size, market share, growth rates, and supplier performance in key areas of bioresearch. This new report continues the analysis of protein expression markets with detailed investigations into expression systems, purification processes, and automated purification systems. 

 

It has already been purchased by astute competitors determined to strengthen their position in this lucrative market. Enhanced by 250 color graphs and tables, this study provides a penetrating analysis and should be considered essential reading for anyone seriously intending to succeed in this competitive area. The 83 companies mentioned in the report are listed in the following table.

 

Companies Mentioned in This Report

Abcam

AbD Serotec/MorphoSys

Abnova

Active Motif

Agilent

Amaxa

Anatrace

Applied Biosystems/Ambion

ATCC

Avestin

BD Biosciences/Pharmingen

Beckman Coulter

Bio-Rad Laboratories

Bioline

Boehringer

Cambridge Isotope Lab

Cell Signaling Technologies

CellFree Sciences

Corning

Cosmo Sciences

EKA Chemicals/Kromasil

EMD/Novagen

Exon Biosciences

Fermentas

GE Healthcare

GeneCopoeia

Genlantis

GenWay

Genzyme

IBA

INiRON Biotechnology

Integra

Invitrogen

Invitrotech

Jackson Labs

Kontes

Lambda Biotech

Lonza

Machery-Nagel

Magellan Biosciences/ESA

MDS

MediaTech

Merck

Millipore

MO BIO Labs

Nalgene

New England Biolabs

NUNC

Omega

Orbigen

PeproTech

PerkinElmer

Promega

Qbiogene

Qiagen

R&D Systems

Research Corporation

Roche

RPI

Santa Cruz Biotechnology

Sartorius/Vivascience

Shiseido Fine Chemicals

Sigma-Aldrich

Sorbent Technologies

Spectra

Stratagene

SUMO

SuperArray

SynBioSci

Takara Bio/Clontech

Teknova

Teledyne/ISCO

Thermo Fisher

Tosoh Haas

Upstate

USB

US Biologics

Varian

VWR

Wako Pure Chemicals

Waters

Whatman

Zymo Research

 

 

A detailed summary of the report including table of contents and list of tables and graphs, as well as the methodology and project objectives, the survey demographics, and a copy of the survey questionnaire can be downloaded from link at the bottom of this page..

 

 

Original press release for this reportSee original press release for this report in Adobe Acrobat format.

Detailed contents, methodology, demographics, and questionnaire for this reportSee detailed contents, methodology, demographics, and questionnaire for this report in Adobe Acrobat format.

To order this report, click here.