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2002/2003 US MSPPSA report on DNA Amplification Reagents & Methodology

168 pages, 201 graphs and tables

Published: July 16, 2002

Price: $3595


In-depth Analysis of Thermostable Enzyme Market Highlights Rapid and Slow Growth Sectors

PhorTech International has released its latest report on the DNA amplification reagent market in the US, providing an in-depth analysis of the thermostable enzyme market. The report is based on the usage and consumption reported by 378 life science researchers with, on average, 8 years of experience with amplification..



The current U.S. thermostable enzyme market is calculated at a whopping $387 million split into 8 major sectors, based upon the procedure involved. This report details the use of kits versus separate enzymes, along with unit and dollar market shares for major suppliers, plus current consumption and projected market growth for each sector separately.


Cycle sequencing is the sector forecast to grow the most slowly over the coming year. In spite of this, it garners a projected +9.4% weighted average growth rate for separate enzymes, kits, and master mixes combined. As can be seen in the graph, no one forecasts growth rates above the 26-50% category, the vast majority of users forecast no change at all, and a few (2.3%) forecast a decrease.



We conduct a similar analysis for 7 other sectors and find growth rates for some areas projected to grow many fold faster than this. Is your company poised to take advantage of these shifts, or will you be caught unable to deliver the necessary kits?


For each of the eight sectors, we calculate suppliers' share of mentions as well as dollar market shares. In the case of hot-start PCR, shown at the top of the next page, we see that Qiagen is the current market leader, pushing past ABI to corner a full third of all dollars spent on this application.


This is the only sector area in which Qiagen leads the market. A total of five different companies lead the market in each of these eight market sectors. Do you know who you are competing against? Do you know which sectors are vital to each of your major competitors?



We also asked respondents to select their current amplification applications from a list of 16 of the most common application areas or a 17th write in choice.




It is immediately apparent that very few researchers, just 5.3%, are working in a single application area. Over 40% cite five applications each while a few researchers report currently using DNA amplification for 12 or more of the applications listed. The predominant applications, used by over half of the respondents to this survey, are cloning PCR products and RT-PCR, which respectively engage 77% and 68% of respondents. This is almost twice the number of researchers using each of the next most frequently mentioned applications.



Respondents were asked to rate suppliers in seven key areas of performance. The ratings for the supplier offering the best value for money are shown above. As can be seen, Promega towers above all other suppliers in this regard. The report goes on to establish ratings for the supplier offering the highest yield, best enzyme for long range PCR, highest specificity, highest fidelity, best product for problematic PCR, and ease of optimization. A total of five different suppliers were ranked highest in these seven areas. Do you know who your customers rank highest in each area? Do you know where your own company stands in comparison?


A large number of demographic screens are used to characterize respondents and the nature of the amplification they performed. These include segmentation by type of organization, scientific discipline and professional position, as well as level of experience. As expected, the bulk of amplification work is found in organizations stressing research and medical applications, such as academia and hospitals. Respondents were not only well-experienced but were holding high level laboratory positions and labeling themselves molecular biologists.

A comprehensive section on amplification methodologies includes an analysis of throughput, applications, the degree to which various enzymes and procedures are used, and the preferences for kits vs reagents. Quantitative values are obtained for typical reaction volumes and type of reaction vessel.


The reasons for choosing the most recent brands of thermostable enzymes purchased, as well as satisfaction with that decision, are measured with high scores for many of the companies supplying to the U.S. market.


Respondents were specifically asked to choose among a list of supplier-derived improvements to point out which would be most important to their work. These covered both enzyme and instrument-related issues and detailed sought after practical, technically-based enhancements.


This report is undoubtedly the most complete analysis of the amplification reagent market and has already been purchased by companies determined to strengthen their position in this lucrative market. With one of the largest datasets to date, and enhanced by over 200 graphs and tables, this study provides an in-depth look at the U.S. amplification userís current needs and future expectations. This report should be considered essential reading for anyone seriously intending to succeed in this increasingly competitive area.


Publication of this report closely follows the publication of the companion report on amplification instrumentation which includes examination of both the traditional thermal cycler market and real-time PCR platforms.


Original press release for this reportSee original press release for this report in Adobe Acrobat format.

Detailed contents, methodology, demographics, and questionnaire for this reportSee detailed contents, methodology, demographics, and questionnaire for this report in Adobe Acrobat format.

To order this report, click here.